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KMID : 0043320180410121170
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Archives of Pharmacal Research
2018 Volume.41 No. 12 p.1170 ~ p.1177
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Limonoids from the roots of Trichilia sinensis and their cytotoxicities
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Liu Shou-Bai
Mei Wen-Li
Chen Hui-Qin
Wang Jun
Wang Zhu-Nian
Dai Hao-Fu
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Abstract
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Six new compounds (1?4, 8, 10), along with six known limonoids (5?7, 9, 11, 12), were isolated from the roots of Trichilia sinensis. Their structures were elucidated on the basis of extensive spectroscopic methods including 1H NMR, 13C NMR, DEPT, HSQC, HMBC, 1H?1H COSY and ROESY experiments, as well as by comparison with the literature. All the compounds were evaluated for cytotoxicities against K562, SGC-7901 and BEL-7402 cell lines. Compounds 2, 7, 10, 11, and 12 showed weak inhibitory activity to the selected cell lines.
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KEYWORD
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Trichilia sinensis, Roots, Trichilin-type limonoids, Cytotoxic activities
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